NOV (gene)

Nephroblastoma overexpressed gene

Identifiers

NOV; CCN3; IGFBP9

External IDs

OMIM: 164958 MGI: 109185 HomoloGene: 1884 GeneCards: NOV Gene

Gene Ontology
Molecular function	• insulin-like growth factor binding • growth factor activity
Cellular component	• extracellular region • axon • dendrite • extracellular matrix • neuronal cell body
Biological process	• regulation of cell growth
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
120.43 – 120.44 Mb

Chr 15:
54.58 – 54.59 Mb

PubMed search

[1]

[2]

Protein NOV homolog is a protein that in humans is encoded by the NOV gene.^[1]^[2]

Interactions

NOV (gene) has been shown to interact with FBLN1^[3] and NOTCH1.^[4]

References

^ Martinerie C, Viegas-Pequignot E, Guenard I, Dutrillaux B, Nguyen VC, Bernheim A, Perbal B (Jan 1993). "Physical mapping of human loci homologous to the chicken nov proto-oncogene". Oncogene 7 (12): 2529–34. PMID 1334251.
^ "Entrez Gene: NOV nephroblastoma overexpressed gene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4856.
^ Perbal, B; Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb. 1999). "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (3): 869–74. doi:10.1073/pnas.96.3.869. ISSN 0027-8424. PMC 15317. PMID 9927660. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15317.
^ Sakamoto, Kei; Yamaguchi Shunji, Ando R, Miyawaki Atsushi, Kabasawa Yuji, Takagi Minoru, Li Chang Long, Perbal Bernard, Katsube Ken-ichi (Aug. 2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. (United States) 277 (33): 29399–405. doi:10.1074/jbc.M203727200. ISSN 0021-9258. PMID 12050162.

Perbal B (2007). "The CCN3 protein and cancer". Adv. Exp. Med. Biol. 587: 23–40. PMID 17163153.
Martinerie C, Huff V, Joubert I et al. (1994). "Structural analysis of the human nov proto-oncogene and expression in Wilms tumor". Oncogene 9 (9): 2729–32. PMID 7520150.
Martinerie C, Chevalier G, Rauscher FJ, Perbal B (1996). "Regulation of nov by WT1: a potential role for nov in nephrogenesis". Oncogene 12 (7): 1479–92. PMID 8622864.
Perbal B, Martinerie C, Sainson R et al. (1999). "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 869–74. doi:10.1073/pnas.96.3.869. PMC 15317. PMID 9927660. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15317.
Burren CP, Wilson EM, Hwa V et al. (1999). "Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily". J. Clin. Endocrinol. Metab. 84 (3): 1096–103. doi:10.1210/jc.84.3.1096. PMID 10084601.
Perbal B (1999). "Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression". MP, Mol. Pathol. 52 (2): 84–91. doi:10.1136/mp.52.2.84. PMC 395679. PMID 10474687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395679.
Albrecht C, von Der Kammer H, Mayhaus M et al. (2000). "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61". J. Biol. Chem. 275 (37): 28929–36. doi:10.1074/jbc.M003053200. PMID 10852911.
Martinerie C, Gicquel C, Louvel A et al. (2001). "Altered expression of novH is associated with human adrenocortical tumorigenesis". J. Clin. Endocrinol. Metab. 86 (8): 3929–40. doi:10.1210/jc.86.8.3929. PMID 11502835.
Manara MC, Perbal B, Benini S et al. (2002). "The expression of ccn3(nov) gene in musculoskeletal tumors". Am. J. Pathol. 160 (3): 849–59. doi:10.1016/S0002-9440(10)64908-5. PMC 1867180. PMID 11891184. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1867180.
Sakamoto K, Yamaguchi S, Ando R et al. (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
Li CL, Martinez V, He B et al. (2002). "A role for CCN3 (NOV) in calcium signalling". MP, Mol. Pathol. 55 (4): 250–61. doi:10.1136/mp.55.4.250. PMC 1187188. PMID 12147716. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1187188.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Thibout H, Martinerie C, Créminon C et al. (2003). "Characterization of human NOV in biological fluids: an enzyme immunoassay for the quantification of human NOV in sera from patients with diseases of the adrenal gland and of the nervous system". J. Clin. Endocrinol. Metab. 88 (1): 327–36. doi:10.1210/jc.2002-020304. PMID 12519873.
Lin CG, Leu SJ, Chen N et al. (2003). "CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family". J. Biol. Chem. 278 (26): 24200–8. doi:10.1074/jbc.M302028200. PMID 12695522.
Ellis PD, Metcalfe JC, Hyvönen M, Kemp PR (2003). "Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1". J. Vasc. Res. 40 (3): 234–43. doi:10.1159/000071887. PMID 12902636.
Laurent M, Martinerie C, Thibout H et al. (2003). "NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism". FASEB J. 17 (13): 1919–21. doi:10.1096/fj.02-1023fje. PMID 14519668.
Lombet A, Planque N, Bleau AM et al. (2003). "CCN3 and calcium signaling". Cell Communication and Signaling 1 (1): 1. doi:10.1186/1478-811X-1-1. PMC 244900. PMID 14606958. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=244900.
Schild C, Trueb B (2004). "Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress". Biochim. Biophys. Acta 1691 (1): 33–40. doi:10.1016/j.bbamcr.2003.12.001. PMID 15053922.
Gellhaus A, Dong X, Propson S et al. (2004). "Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells". J. Biol. Chem. 279 (35): 36931–42. doi:10.1074/jbc.M404073200. PMID 15181016.

NOV (gene)

Interactions

References

Further reading